NX-13
Amelenodor (NX-13) is an orally available, gut-selective molecule that activates the mitochondrial receptor NLRX1 to reduce intestinal inflammation. It promotes oxidative phosphorylation while suppressing proinflammatory pathways like Th1/Th17 differentiation and cytokine production. It has the potential to treat inflammatory bowel disease (IBD).
| Trivial name | Amelenodor |
| Catalog Number | E4755 |
| Molecular Formula | C22H27FN4O2.C4H6O5 |
| CAS# | 2389235-01-0 |
| Inchi | InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7 )(H,8,9)/b17-12-;/t;2-/m.0/s1 |
| Inchi Key | LBWFXVZLPYTWQI-IPOVEDGCSA-N |
| SMILES | CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/nx-13.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4755-NX-13-chemical-structure.png |