NX-13
Amelenodor (NX-13) is an orally available, gut-selective molecule that activates the mitochondrial receptor NLRX1 to reduce intestinal inflammation. It promotes oxidative phosphorylation while suppressing proinflammatory pathways like Th1/Th17 differentiation and cytokine production. It has the potential to treat inflammatory bowel disease (IBD).
| Trivial name | Amelenodor |
| Catalog Number | E4755 |
| Molecular Formula | C21H16ClF3N4O3.C7H8O3S |
| CAS# | 2389235-01-0 |
| Inchi | InChI=1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H ,8,9,10) |
| Inchi Key | IVDHYUQIDRJSTI-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/nx-13.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4755-NX-13-chemical-structure.png |