Cpd. 37
MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.
| Trivial name | MYC-IN-3 |
| Catalog Number | E4750 |
| Molecular Formula | C19H16N4O3 |
| CAS# | 3042878-82-7 |
| Inchi | InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 |
| Inchi Key | TUVCWJQQGGETHL-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/cpd-37.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4750-Cpd-37-chemical-structure.png |