Oveporexton (TAK-861)

Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.

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Catalog Number	E4740
Molecular Formula	C27H29N5O
CAS#	2460722-04-5
Inchi	InChI=1S/C27H29N5O/c28-26-25-24(21-8-4-9-23(14-21)33-17-19-6-2-1-3-7-19)16-32(27(25)30-18-29-26)22-12-20(13-22)15-31-10-5-11-31/h1-4,6-9,14,16,18,20,22H,5,10-13,15,17H2,(H2,28,29,30)/t20-,22+
Inchi Key	AECDBHGVIIRMOI-GRGXKFILSA-N
SMILES	C1CN(C1)CC2CC(C2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Size	5mg
Supplier Page	http://www.selleckchem.com/products/tak-861.html
Additional Information	https://file.selleck.cn/downloads/struct/E4740-TAK-861-chemical-structure.png