MGD-28
MGD-28 is a potent and orally active degrader of Cereblon (CRBN)-dependent IKAROS proteins. It effectively degrades IKZF1 (DC50 = 3.8 nM), IKZF2 (DC50 = 56.3 nM), and IKZF3 (DC50 = 7.1 nM). It demonstrates significant antiproliferative potency across various hematologic cancer cell lines.
| Catalog Number | E4724 |
| Molecular Formula | C22H24ClFN4O3 |
| CAS# | 2991818-13-2 |
| Inchi | InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) |
| Inchi Key | XGALLCVXEZPNRQ-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/mgd-28.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4724-MGD-28-chemical-structure.png |