GNE-495
GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.
| Catalog Number | E4722 |
| Molecular Formula | C20H30N4O2 |
| CAS# | 1449277-10-4 |
| Inchi | InChI=1S/C20H30N4O2/c1-4-5-6-11-26-17-9-7-16(8-10-17)23-20(25)18-13-21-24-15(3)12-14(2)22-19(18)24/h12-13,16-17H,4-11H2,1-3H3,(H,23,25)/t16-,17- |
| Inchi Key | HZILSILAELSWKN-QAQDUYKDSA-N |
| SMILES | CCCCCOC1CCC(CC1)NC(=O)C2=C3N=C(C=C(N3N=C2)C)C |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/gne-495.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4722-GNE-495-chemical-structure.png |