SDU-071
SDU-071 is an inhibitor of BRD4-p53 protein-protein interaction with IC50 of 2.7 μM, which suppresses MDA-MB-231 triple-negative breast cancer (TNBC) cell migration, invasion, and in vivo tumor growth. It also exhibits antiproliferative activity in concentration concentration-dependent manner, with IC50 of 10.5 μM (72 h) and 12.6 μM (96 h) in MDA-MB-231 cells.
| Catalog Number | E4712 |
| Molecular Formula | C19H25BN4O4 |
| CAS# | 3036109-10-8 |
| Inchi | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| Inchi Key | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| SMILES | B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sdu-071.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4712-SDU-071-chemical-structure.png |