JAB-3312
JAB-3312 is a potent allosteric inhibitor of SHP2 with an IC50 of 1.9 nM and a Kd of 0.37 nM. It is a potential anticancer agent and can be used in cancer research.
| Catalog Number | E4705 |
| Molecular Formula | C24H25ClFN5O3 |
| CAS# | 2245082-05-5 |
| Inchi | InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1 |
| Inchi Key | ULXXDDBFHOBEHA-CWDCEQMOSA-N |
| SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/jab-3312.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4705-JAB-3312-chemical-structure.png |