D34-919
D34-919 is potent inhibitor of the ALDH1A3-PKM2 interaction, and prevents the ALDH1A3-mediated enhancement of PKM2 tetramerization. D34-919 mediated in vitro and in vivo treatment enhances and restores chemoradiotherapy-induced apoptosis and sensitivity in glioblastoma (GBM) cells.
| Catalog Number | E4704 |
| Molecular Formula | C31H33N5O4 |
| CAS# | 1011641-78-3 |
| Inchi | InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28- |
| Inchi Key | XZXHXSATPCNXJR-ZIADKAODSA-N |
| SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N=C(C3=CC=CC=C3)C4=C(NC5=C4C=CC(=C5)C(=O)OC)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/d34-919.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4704-D34-919-chemical-structure.png |