Culmerciclib
Culmerciclib (TQB3616) is a potent inhibitor of cyclin dependent kinase (CDK)4/6 and exhibits highly effective antineoplastic activity. TQB3616 exhibits significant synergistic antitumor activity in estrogen receptor (ER)-positive/HER2-negative or HER2-positive breast cancer when combined with endocrine therapy or Human Epidermal Growth Factor Receptor 2 (HER2) targeted therapy.
| Trivial name | TQB3616 |
| Catalog Number | E4703 |
| Molecular Formula | C17H15BrClFN4O3 |
| CAS# | 2004705-28-4 |
| Inchi | InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| Inchi Key | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/culmerciclib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4703-Culmerciclib-chemical-structure.png |