Oligomycin is a macrolide antibiotic produced by Streptomyces. It is a mixture of three oligomycin isomers, namely Oligomycin A, B and C. Oligomycin is an inhibitor of mitochondrial F0 subunit H+-ATP synthase, which can disrupt oxidative phosphorylation and the electron transport chain. It can inhibit TNF-induced apoptosis and can be used as an antifungal antibiotic.