GW280264X
GW280264X is a potent hydroxamate inhibitor of mixed ADAM10/TACE (ADAM17). It potently blocks TACE (ADAM17) and ADAM10 with IC50s of 8.0 nM and 11.5 nM, respectively. It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells. Its treatment significantly improves functional recovery after spinal cord injury.
| Catalog Number | E1012 |
| Molecular Formula | C35H41ClN6O4 |
| CAS# | 866924-39-2 |
| SMILES | CC(C)OC1=CC=C(CN2CCNCC2)C=C1N3C(=NC4=C(C=CC=C4)C3=O)CN5CCN(CC5)C(=O)COC6=CC=C(Cl)C=C6 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/gw280264x.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E1012-GW280264X-chemical-structure.png |