Norfluoxetine is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine is approved for the treatment of major depression (including pediatric depression), obsessive-compulsive disorder (in both adult and pediatric populations), bulimia nervosa, panic disorder and premenstrual dysphoric disorder. Fluoxetine is metabolized in the liver by isoenzymes of the cytochrome P450 system, including CyP2D6.