Pemetrexed

Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) to 2′-deoxythymidine-5′-monophosphate (dTMP), an essential precursor in DNA synthesis.

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Catalog Number INT137281233
Alternative Name(s) Pemetrexed disodium Alimta LY231514
Research Area Intermediates
Molecular Formula C₂₀H₂₁N₅O₆
CAS# 137281-23-3
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)O)C(=O)O
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