6-Chloro-2-fluoropurine is used as a reagent in the synthesis of several organic compounds including that of 2”-Fluoro-3”-Hydroxymethyl-5”-deoxythreosyl phosphonic acid nucleoside analogues which may potentially act as antiviral agents. It is also used in the synthesis of 2”,5”,5”-trifluoro-3”-hydroxy-apiosyl nucleoside phosphonic acid analogues which may possess potent anti-HCMV properties.