Moxidectin is a semi-synthetic single component macrolide antibiotic produced by Streptomyces fermentation, and is a derivative of nimoxetine. The macrolide class of antiparasitic drugs consists of two main classes, namely avermectin and Milbemycin.

Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals.