Dexrazoxane, also referred to as ADR-529, is an organo-metallic compound widely employed in scientific research. It inhibits Topo II (DNA topoisomerase II) without inducing DNA strand breaks. Dexrazoxane is a (+)enantiomer of razoxane (sc-253425). Dexrazoxane also decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway. Furthermore, dexrazoxane is thought to inhibit the activity of topoisomerase II.