MCUF-651 | MedChemExpress (MCE)
MCUF-651 is an orally active guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM) (KD: 397 nM ). MCUF-651 binds to GC-A and selectively enhances the binding of atrial natriuretic peptide (ANP) to GC-A. MCUF-651 enhances ANP-mediated cGMP generation in human cardiac, renal, and fat cells. MCUF-651 inhibits cardiomyocyte hypertrophy[1].
| Trivial name | MCUF-651 |
| Catalog Number | HY-149453 |
| Research Area | Cardiovascular Disease |
| CAS# | 2747162-85-0 |
| Purity | ≥98.0% |
| SMILES | O=C(C1CN(CCC1)CCN(C)C)NC2=NC3=C(S2)C=C(F)C=C3F |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/mcuf-651.html |