SIK-IN-1 | MedChemExpress (MCE)
SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 4 nM in human macrophages[1].
| Trivial name | SIK-IN-1 |
| Catalog Number | HY-161440 |
| Research Area | Inflammation/Immunology |
| CAS# | 3033846-29-3 |
| Purity | ≥98.0% |
| SMILES | N#CC1=C(NC)C=CC2=NC=C(C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3)N21 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/sik-in-1.html |