TOPOI/PARP-1-IN-1 | MedChemExpress (MCE)
TOPOI/PARP-1-IN-1 (Compound B6) is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC50 value of 0.09 μM for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate (TGI) of TOPOI/PARP-1-IN-1 in mice was 75.4%[1].
| Trivial name | TOPOI/PARP-1-IN-1 |
| Catalog Number | HY-158138 |
| Research Area | Cancer |
| CAS# | 2948352-16-5 |
| Purity | ≥98.0% |
| SMILES | O=C(N([C@@]([H])([C@]1(CCCN2CCC3)[H])CCCC4=NC(C=C(C(Br)=C5)Br)=C5N4)C[C@@]3([H])[C@@]12[H])OCC6C7=C(C8=C6C=CC=C8)C=CC=C7 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/topoi-parp-1-in-1.html |