LC-1-40 | MedChemExpress (MCE)
LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM). LC-1-40 selectively inhibits MYCN-induced tumor growth in mouse models. LC-1-40 also induces nucleotide damage and apoptosis in MYCN-associated tumors. LC-1-40 can be used in cancer research[1]. (Red: NUDT1 binder; Blue: CRBN ligand; Black: Linker).
| Trivial name | LC-1-40 |
| Catalog Number | HY-158062 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CC5CCN(CC5)C(C6=CC=C(C=C6)C7=CC=C8N=CC(C(NC9CC9)=O)=C(C8=C7)NC%10=CC=CC=C%10)=O)=O |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/lc-1-40.html |