PRMT5/EGFR-IN-1 | MedChemExpress (MCE)
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC50s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors[1].
| Trivial name | PRMT5/EGFR-IN-1 |
| Catalog Number | HY-163434 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | COC1=CC(C2NCCC3=C2NC4=CC=CC=C43)=CC=C1OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/prmt5-egfr-in-1.html |