Poziotinib | MedChemExpress (MCE)
Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity[1][2].
| Trivial name | Poziotinib |
| Catalog Number | HY-15730 |
| Alternative Name(s) | HM781-36B; NOV120101 |
| Research Area | Cancer |
| CAS# | 1092364-38-9 |
| Purity | 100.0% |
| SMILES | C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O |
| Size | 10 mg |
| Supplier Page | https://www.medchemexpress.com/Poziotinib.html |