Polθ/PARP-IN-1 | MedChemExpress (MCE)
Polθ/PARP-IN-1 (compound 25d) is a potent dual DNA polymerase theta (Polθ) and PARP inhibitor with IC50 values of 45.6, 5.4 nM, respectively. Polθ/PARP-IN-1 shows antiproliferative activity. Polθ/PARP-IN-1 induces apoptosis and cell cycle arrest at G2/M phase, causes DNA damage. Polθ/PARP-IN-1 shows anti-tumor activity[1].
| Trivial name | Polθ/PARP-IN-1 |
| Catalog Number | HY-161302 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | COC1=CC=C(C=C1C2=CC(C)=NC=C2C(NC3=NN=C(S3)OCC4CCN(CC4)C(C5=C(C=CC(CC6=NNC(C7=C6C=CC=C7)=O)=C5)F)=O)=O)Cl |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/polθ-parp-in-1.html |