PI-540 | MedChemExpress (MCE)
PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ). PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM)[1].
| Trivial name | PI-540 |
| Catalog Number | HY-10116 |
| Research Area | Cancer |
| CAS# | 885616-78-4 |
| Purity | ≥98.0% |
| SMILES | OC1=CC=CC(C2=NC(N3CCOCC3)=C(SC(CN4CCN(C)CC4)=C5)C5=N2)=C1 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/pi-540.html |