Pomalidomide-NH-PEG6-amide-C2-CPI-1612 | MedChemExpress (MCE)
Pomalidomide-NH-PEG6-amide-C2-CPI-1612 (compound 22 (dCE-1)) is a CBP/EP300 degrader, which contains a CRBN ligands Pomalidomide, a 24-atom linker with 6 PEG units and a HAT inhibitor CPI-1612. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 exhibits antiproliferative effects in cells multiple myeloma cells LP1 (with a DC50 of 1.2 μM), MM1S and various cancer cell lines, especially the leukemia cells[1].
| Trivial name | Pomalidomide-NH-PEG6-amide-C2-CPI-1612 |
| Catalog Number | HY-161250 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C(N(C(C(N1)=O)CCC1=O)C2=O)C3=C2C(NCCOCCOCCOCCOCCOCCOCCNC(CCCN4N=CC(C5=CC=C(NC([C@@H](C6=CC=CC=C6)NC[C@@H](C)C7=CC=C(C#N)C=C7)=O)N=C5)=C4)=O)=CC=C3 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/pomalidomide-nh-peg6-amide-c2-cpi-1612.html |