Entrectinib-d8 | MedChemExpress (MCE)
Entrectinib-d8 (NMS-E628-d8; RXDX-101-d8) is a deuterated version of Entrectinib (HY-12678). Entrectinib (NMS-E628) is an orally available, blood-brain barrier permeable, central nervous system active TrkA/B/C, ROS1 and ALK inhibitor with IC50 values of 1, 3, 5, 12 and 12, respectively. 7 nM. Entrectinib induces apoptosis and cycle arrest in cancer cells, has anti-tumor activity, and also alleviates bleomycin-induced pulmonary fibrosis in mice[1][2][3][4].
| Trivial name | Entrectinib-d8 |
| Catalog Number | HY-12678S1 |
| Alternative Name(s) | NMS-E628-d8; RXDX-101-d8 |
| Research Area | Cancer |
| CAS# | 2251773-94-9 |
| Purity | 99.8% |
| SMILES | O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C6([2H])[2H])C=C4 |
| Size | 10 mg |
| Supplier Page | https://www.medchemexpress.com/entrectinib-d8.html |