Entrectinib-d4 | MedChemExpress (MCE)
Entrectinib-d4 (NMS-E628-d4; RXDX-101-d4) is the deuterium labeled Entrectinib (HY-12678). Entrectinib is an orally active, BBB-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Entrectinib induces apoptosis and cycle arrest in cancer cells, has antitumor activity, and attenuates bleomycin-induced lung fibrosis in mice[1][2][3].
| Trivial name | Entrectinib-d4 |
| Catalog Number | HY-12678S |
| Alternative Name(s) | NMS-E628-d4; RXDX-101-d4 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5C([2H])([2H])COCC5([2H])[2H])C=C(N6CCN(C)CC6)C=C4 |
| Size | 5 mg |
| Supplier Page | https://www.medchemexpress.com/entrectinib-d4.html |