Pirtobrutinib (LOXO-305)
Pirtobrutinib (LOXO-305, LY 3527727, RXC-005) is a highly selective, non-covalent, next generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells. Pirtobrutinib shows more than 300-fold selective for BTK over 98% of 370 other kinases.
| Trivial name | LY 3527727, RXC-005 |
| Catalog Number | S9825 |
| Molecular Formula | C22H21F4N5O3 |
| CAS# | 2101700-15-4 |
| Inchi | #N/A |
| Inchi Key | #N/A |
| SMILES | COC1=CC=C(F)C=C1C(=O)NCC2=CC=C(C=C2)C3=N[N](C(C)C(F)(F)F)C(=C3C(N)=O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pirtobrutinib-loxo-305.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s9825-loxo-305-chemical-structure.gif |