Tuxobertinib (BDTX-189)
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations with Kd of 0.2 nM, 0.76 nM, 13 nM and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. BDTX-189 exhibits anticancer activity.
Trivial name | N/A |
Catalog Number | S9786 |
Molecular Formula | C₂₉H₂₉ClN₆O₄ |
CAS# | 2414572-47-5 |
Inchi | #N/A |
Inchi Key | #N/A |
SMILES | ClC1=C(OCC2=NC=CC=C2)C=CC(=C1)NC3=NC=NC4=C3C=C(NC(=O)C=C)C(=C4)OCCN5CCOCC5 |
Size | 10mM/1mL |
Supplier Page | http://www.selleckchem.com/products/bdtx-189.html |
Additional Information | https://file.selleck.cn/downloads/struct/s9786-bdtx-189-chemical-structure.gif |