JHU-083
JHU-083 (Ethyl 2-(2-Amino-4-methylpentanamido)-DON) is a novel prodrug of DON.JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.Solutions are unstable and should be fresh-prepared.
| Trivial name | Ethyl 2-(2-Amino-4-methylpentanamido)-DON |
| Catalog Number | S8891 |
| Molecular Formula | C14H24N4O4 |
| CAS# | 1998725-11-3 |
| Inchi | InChI=1S/C14H24N4O4/c1-4-22-14(21)12(6-5-10(19)8-17-16)18-13(20)11(15)7-9(2)3/h8-9,11-12H,4-7,15H2,1-3H3,(H,18,20)/t11-,12-/m0/s1 |
| Inchi Key | YZRCHOFKIPHQBW-RYUDHWBXSA-N |
| SMILES | CCOC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)C(CC(C)C)N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/jhu-083.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s8891-jhu-083-chemical-structure.png |