Belvarafenib
Belvarafenib is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively.
| Trivial name | HM95573, GDC5573, RG6185 |
| Catalog Number | S8853 |
| Molecular Formula | C23H16ClFN6OS |
| CAS# | 1446113-23-0 |
| Inchi | InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29) |
| Inchi Key | KVCQTKNUUQOELD-UHFFFAOYSA-N |
| SMILES | CC1=C(C2=C(C=C1)C(=NC=C2)NC3=C(C(=CC=C3)Cl)F)NC(=O)C4=CSC5=C4N=CN=C5N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/belvarafenib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/belvarafenib-chemical-structure-s8853.gif |