AZD3229
AZD3229 is a potent, pan-Kit (c-Kit) mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant Kit (c-Kit) driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).
| Trivial name | N/A |
| Catalog Number | S8780 |
| Molecular Formula | C24H26FN7O3 |
| CAS# | 2248003-60-1 |
| Inchi | InChI=1S/C24H26FN7O3/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24/h4-7,10-12,14-15H,8-9,13H2,1-3H3,(H,28,33)(H,26,27,29) |
| Inchi Key | FLJOFQUXYAWOPE-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CN(N=N1)CC(=O)NC2=CC=C(C=C2)NC3=NC=NC4=C3C(=CC(=C4)OCCOC)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/azd3229.html |
| Additional Information | https://file.selleck.cn/downloads/struct/azd3229-chemical-structure-s8780.gif |