Adavivint (SM04690)

Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.

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Trivial name	Lorecivivint
Catalog Number	S8761
Molecular Formula	C29H24FN7O
CAS#	1467093-03-3
Inchi	InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28(37-36-24)29-34-25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,(H,33,38)(H,34,35)(H,36,37)
Inchi Key	AQDWDWAYVBQMAM-UHFFFAOYSA-N
SMILES	CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C(C=C2)NN=C3C4=NC5=C(N4)C=NC=C5C6=CC(=CC=C6)F
Size	1g
Supplier Page	http://www.selleckchem.com/products/adavivint.html
Additional Information	https://file.selleck.cn/downloads/struct/adavivint-sm04690-chemical-structure-s8761.gif