VU661013

VU661013 is a novel, potent, selective MCL1 inhibitor with Ki of 97 ± 30 pM of human MCL-1 in a TR-FRET assay. However, VU661013 does not significantly inhibit BCL-xL or BCL-2 with Ki > 40 μM or = 0.73 μM. VU661013 de-stabilizes BIM/MCL-1 association, leads to apoptosis in AML.

Price Not Available 10mM/1mL VU661013 Supplier Page

Trivial name	N/A
Catalog Number	S8758
Molecular Formula	C39H39Cl2N5O4
CAS#	2131184-57-9
SMILES	CC1CN(C(=O)C2=C(C3=C(N12)C(=C(C=C3)Cl)C4=C(N(N=C4C)C)C)CCCOC5=CC(=C(C(=C5)C)Cl)C)C6=CN(C7=C6C=C(C=C7)C(=O)O)C
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/vu661013.html
Additional Information	https://file.selleck.cn/downloads/struct/vu661013-chemical-structure-s8758.gif