Alofanib (RPT835)
Alofanib (RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding.
| Trivial name | N/A |
| Catalog Number | S8754 |
| Molecular Formula | C19H15N3O6S |
| CAS# | 1612888-66-0 |
| Inchi | InChI=1S/C19H15N3O6S/c1-12-8-18(22(25)26)17(10-16(12)14-5-3-7-20-11-14)21-29(27,28)15-6-2-4-13(9-15)19(23)24/h2-11,21H,1H3,(H,23,24) |
| Inchi Key | QUQGQIASFYWKAB-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1C2=CN=CC=C2)NS(=O)(=O)C3=CC=CC(=C3)C(=O)O)[N+](=O)[O-] |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/alofanib-rpt835.html |
| Additional Information | https://file.selleck.cn/downloads/struct/alofanib-rpt835-chemical-structure-s8754.gif |