Atuveciclib (BAY-1143572)
Atuveciclib (BAY-1143572) is a potent and highly selective PTEFb/CDK9 inhibitor with IC50 values of 13 nM for CDK9/CycT and the ratio of IC50 values for CDK2/CDK9 is about 100. Outside the CDK family, It inhibits GSK3 kinase with IC50 values of 45 nM and 87 nM for GSK3α and GSK3β respectively.
| Trivial name | N/A |
| Catalog Number | S8727 |
| Molecular Formula | C18H18FN5O2S |
| CAS# | 1414943-88-6 |
| Inchi | InChI=1S/C18H18FN5O2S/c1-26-16-9-13(19)6-7-15(16)17-21-11-22-18(24-17)23-14-5-3-4-12(8-14)10-27(2,20)25/h3-9,11,20H,10H2,1-2H3,(H,21,22,23,24) |
| Inchi Key | ACWKGTGIJRCOOM-UHFFFAOYSA-N |
| SMILES | COC1=C(C=CC(=C1)F)C2=NC(=NC=N2)NC3=CC=CC(=C3)CS(=N)(=O)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/atuveciclib-bay-1143572.html |
| Additional Information | https://file.selleck.cn/downloads/struct/atuveciclib-bay-1143572-chemical-structure-s8727.gif |