Tanzisertib(CC-930)
Tanzisertib (CC-930, JNK-930, JNKI-1) is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively.
| Trivial name | JNK-930, JNKI-1 |
| Catalog Number | S8490 |
| Molecular Formula | C21H23F3N6O2.HCl |
| CAS# | 899805-25-5(freebase) |
| Inchi | InChI=1S/C21H23F3N6O2.ClH/c22-11-7-15(23)18(16(24)8-11)28-21-27-17-9-25-20(26-12-1-3-14(31)4-2-12)29-19(17)30(21)13-5-6-32-10-13;/h7-9,12-14,31H,1-6,10H2,(H,27,28)(H,25,26,29);1H/t12-,13-,14-;/m0./s1 |
| Inchi Key | BTKXDTOPRHDNSM-JKBZPBJLSA-N |
| SMILES | C1CC(CCC1NC2=NC=C3C(=N2)N(C(=N3)NC4=C(C=C(C=C4F)F)F)C5CCOC5)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/cc-930.html |
| Additional Information | https://file.selleck.cn/downloads/struct/cc-930-chemical-structure-S8490.gif |