KPT 9274 (ATG-019)

KPT 9274 ( ATG-019) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

Price Not Available 10mM/1mL KPT 9274 (ATG-019) Supplier Page

Trivial name	N/A
Catalog Number	S8444
Molecular Formula	C35H29F3N4O3
CAS#	1643913-93-2
Inchi	InChI=1S/C35H29F3N4O3/c36-28-9-7-24(8-10-28)30-19-26(23-3-5-25(6-4-23)34(44)42-15-13-35(37,38)14-16-42)17-27-18-29(45-33(27)30)21-41-32(43)12-2-22-1-11-31(39)40-20-22/h1-12,17-20H,13-16,21H2,(H2,39,40 )(H,41,43)/b12-2+
Inchi Key	MRFOPLWJZULAQD-SWGQDTFXSA-N
SMILES	C1CN(CCC1(F)F)C(=O)C2=CC=C(C=C2)C3=CC(=C4C(=C3)C=C(O4)CNC(=O)C=CC5=CN=C(C=C5)N)C6=CC=C(C=C6)F
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/kpt-9274.html
Additional Information	https://file.selleck.cn/downloads/struct/kpt-9274-chemical-structure-s8444.gif