MK-8617
MK-8617 is an orally active pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1−3 (HIF PHD1−3), inhibiting PHD1, 2, 3 with IC50s of 1.0, 1.0 and 14 nM, respectively.
| Trivial name | N/A |
| Catalog Number | S8443 |
| Molecular Formula | C24H21N5O4 |
| CAS# | 1187990-87-9 |
| Inchi | InChI=1S/C24H21N5O4/c1-32-17-9-5-15(6-10-17)21(16-7-11-18(33-2)12-8-16)27-23(30)19-14-25-22(28-24(19)31)20-4-3-13-26-29-20/h3-14,21H,1-2H3,(H,27,30)(H,25,28,31) |
| Inchi Key | WXLPERVDMILVIF-UHFFFAOYSA-N |
| SMILES | COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)NC(=O)C3=CN=C(NC3=O)C4=NN=CC=C4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/mk-8617.html |
| Additional Information | https://file.selleck.cn/downloads/struct/mk-8617-chemical-structure-S8443.gif |