CAY10585 (LW 6)

CAY10585 (LW 6) is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. LW6 inhibits HIF and MDH2 expression with IC50 values of 4.4 and 6.3 μM, respectively.

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Trivial name	AC1-001
Catalog Number	S8441
Molecular Formula	C26H29NO5
CAS#	934593-90-5
Inchi	InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)
Inchi Key	BJRPPNOJYFZSLY-UHFFFAOYSA-N
SMILES	COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/lw-6.html
Additional Information	https://file.selleck.cn/downloads/struct/lw-6-chemical-structure-s8441.gif