CAY10585 (LW 6)
CAY10585 (LW 6) is a hypoxia-inducible factor 1(HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. LW6 inhibits HIF and MDH2 expression with IC50 values of 4.4 and 6.3 μM, respectively.
| Trivial name | AC1-001 |
| Catalog Number | S8441 |
| Molecular Formula | C26H29NO5 |
| CAS# | 934593-90-5 |
| Inchi | InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29) |
| Inchi Key | BJRPPNOJYFZSLY-UHFFFAOYSA-N |
| SMILES | COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/lw-6.html |
| Additional Information | https://file.selleck.cn/downloads/struct/lw-6-chemical-structure-s8441.gif |