KG-501
KG-501 is a cAMP response element-binding protein (CREB) inhibitor that disrupts CREB-dependent transcription (Ki = 10 μM) and CREB:CBP interaction (Ki = 50 μM). It also disrupts phospho (Ser-133) CREB binding to KIX with a Ki of ≈90 μM, using concentrations of CREB that were within the linear range of the binding assay.
| Trivial name | 2-naphthol-AS-E-phosphate |
| Catalog Number | S8409 |
| Molecular Formula | C17H13ClNO5P |
| CAS# | 18228-17-6 |
| Inchi | InChI=1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23) |
| Inchi Key | RQAQWBFHPMSXKR-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)OP(=O)(O)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/kg-501-2-naphthol-as-e-phosphate.html |
| Additional Information | https://file.selleck.cn/downloads/struct/kg-501-2-naphthol-as-e-phosphate-chemical-structure-s8409.gif |