Mivebresib (ABBV-075)

Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. It binds bromodomains of BRD2/4/T with similar affinities (Ki of 1-2.2 nM) and highly selective for 18 bromodomain proteins tested (Kd > 1 μM; more than 600-fold selectivity vs. BRD4), but exhibits roughly 10-fold weaker potency towards BRD3 (Ki of 12.2 nM) and has moderate activity towards CREBBP (Kd = 87 μM; 54-fold selectivity vs. BRD4). Mivebresib(ABBV-075) efficiently triggers apoptosis in various tumor cell.

Price Not Available 1g Mivebresib (ABBV-075) Supplier Page

Trivial name	N/A
Catalog Number	S8400
Molecular Formula	C22H19F2N3O4S
CAS#	1445993-26-9
Inchi	InChI=1S/C22H19F2N3O4S/c1-3-32(29,30)26-14-5-7-19(31-20-6-4-13(23)10-18(20)24)16(11-14)17-12-27(2)22(28)21-15(17)8-9-25-21/h4-12,25-26H,3H2,1-2H3
Inchi Key	RDONXGFGWSSFMY-UHFFFAOYSA-N
SMILES	CCS(=O)(=O)NC1=CC(=C(C=C1)OC2=C(C=C(C=C2)F)F)C3=CN(C(=O)C4=C3C=CN4)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/mivebresib-abbv-075.html
Additional Information	https://file.selleck.cn/downloads/struct/mivebresib-abbv-075-chemical-structure-S8400.gif