UNC3866
UNC3866 is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains. UNC3866 binds the chromodomains of CBX4 and CBX7 most potently, with a K(d) of ∼100 nM for each, and is 6- to 18-fold selective as compared to seven other CBX and CDY chromodomains.
| Trivial name | N/A |
| Catalog Number | S8359 |
| Molecular Formula | C43H66N6O8 |
| CAS# | 1872382-47-2 |
| Inchi | InChI=1S/C43H66N6O8/c1-10-49(11-2)24-16-15-19-33(39(53)48-36(27-50)42(56)57-9)45-41(55)34(25-28(3)4)46-37(51)29(5)44-40(54)35(26-30-17-13-12-14-18-30)47-38(52)31-20-22-32(23-21-31)43(6,7)8/h12-14,17-1 8,20-23,28-29,33-36,50H,10-11,15-16,19,24-27H2,1-9H3,(H,44,54)(H,45,55)(H,46,51)(H,47,52)(H,48,53)/t29-,33-,34-,35-,36-/m0/s1 |
| Inchi Key | UMRRDXVUROEIKJ-JCXBGQGISA-N |
| SMILES | CCN(CC)CCCCC(C(=O)NC(CO)C(=O)OC)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C(C)(C)C |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/unc3866.html |
| Additional Information | https://file.selleck.cn/downloads/struct/unc3866-chemical-structure-s8359.gif |