AZD5153 6-hydroxy-2-naphthoic acid

AZD5153 6-hydroxy-2-naphthoic acid (HNT salt) is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor with pKi of 8.3 for BRD4. AZD5153 inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes. NSD3, via H3K36me2, acts as an epigenetic deregulator to facilitate the expression of oncogenesis-promoting genes.

Price Not Available 100mg AZD5153 6-hydroxy-2-naphthoic acid Supplier Page

Trivial name	AZD5153 HNT salt
Catalog Number	S8344
Molecular Formula	C25H33N7O3.C11H8O3
CAS#	1869912-40-2
Inchi	InChI=1S/C25H33N7O3.C11H8O3/c1-18-24(33)29(2)14-15-30(18)16-17-35-21-6-4-19(5-7-21)20-10-12-31(13-11-20)23-9-8-22-26-27-25(34-3)32(22)28-23;12-10-4-3-7-5-9(11(13)14)2-1-8(7)6-10/h4-9,18,20H,10-17H2,1- 3H3;1-6,12H,(H,13,14)/t18-;/m1./s1
Inchi Key	UNZQBHXKCHECEC-GMUIIQOCSA-N
SMILES	CC1C(=O)N(CCN1CCOC2=CC=C(C=C2)C3CCN(CC3)C4=NN5C(=NN=C5OC)C=C4)C.C1=CC2=C(C=CC(=C2)O)C=C1C(=O)O
Size	100mg
Supplier Page	http://www.selleckchem.com/products/azd5153-6-hydroxy-2-naphthoic-acid.html
Additional Information	https://file.selleck.cn/downloads/struct/azd5153-chemical-structure-S8344.gif