PF-06409577
PF-06409577 is an orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.
| Trivial name | N/A |
| Catalog Number | S8335 |
| Molecular Formula | C19H16ClNO3 |
| CAS# | 1467057-23-3 |
| Inchi | InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23) |
| Inchi Key | FHQXLWCFSUSXBF-UHFFFAOYSA-N |
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/pf-06409577.html |
| Additional Information | https://file.selleck.cn/downloads/struct/pf-06409577-chemical-structure-s8335.gif |