PLX8394
PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.
| Trivial name | N/A |
| Catalog Number | S7965 |
| Molecular Formula | C25H21F3N6O3S |
| CAS# | 1393466-87-9 |
| Inchi | InChI=1S/C25H21F3N6O3S/c26-16-5-6-34(12-16)38(36,37)33-20-4-3-19(27)21(22(20)28)23(35)18-11-32-25-17(18)7-14(8-31-25)15-9-29-24(30-10-15)13-1-2-13/h3-4,7-11,13,16,33H,1-2,5-6,12H2,(H,31,32)/t16-/m1/s1 |
| Inchi Key | YYACLQUDUDXAPA-MRXNPFEDSA-N |
| SMILES | C1CC1C2=NC=C(C=N2)C3=CC4=C(NC=C4C(=O)C5=C(C=CC(=C5F)NS(=O)(=O)N6CCC(C6)F)F)N=C3 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/plx8394.html |
| Additional Information | https://file.selleck.cn/downloads/struct/plx8394-chemical-structure-s7965.gif |