PLX7904
PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.
| Trivial name | PB04 |
| Catalog Number | S7964 |
| Molecular Formula | C24H22F2N6O3S |
| CAS# | 1393465-84-3 |
| Inchi | InChI=1S/C24H22F2N6O3S/c1-3-32(2)36(34,35)31-19-7-6-18(25)20(21(19)26)22(33)17-12-30-24-16(17)8-14(9-29-24)15-10-27-23(28-11-15)13-4-5-13/h6-13,31H,3-5H2,1-2H3,(H,29,30) |
| Inchi Key | DKNZQPXIIHLUHU-UHFFFAOYSA-N |
| SMILES | CCN(C)S(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CN=C(N=C4)C5CC5)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/plx7904.html |
| Additional Information | https://file.selleck.cn/downloads/struct/plx7904-chemical-structure-s7964.gif |