Nazartinib (EGF816)

Nazartinib (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.

Price Not Available 10mM/1mL Nazartinib (EGF816) Supplier Page

Trivial name	NVS-816
Catalog Number	S7824
Molecular Formula	C26H31ClN6O2
CAS#	1508250-71-2
Inchi	InChI=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33(26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5,8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s 1
Inchi Key	IOMMMLWIABWRKL-WUTDNEBXSA-N
SMILES	CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2C4CCCCN(C4)C(=O)C=CCN(C)C)C(=CC=C3)Cl
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/nazartinib-egf816-nvs-816.html
Additional Information	https://file.selleck.cn/downloads/struct/nazartinib-egf816-nvs-816-chemical-structure-S7824.gif